USDOE Human Subjects Research Database Summary, Fiscal Year 1999

Listing of project identifier, principal investigator, funding, number of human subjects, and project title.



DOE Facilities:
Project IdentifierPrincipal Investigator Funding# Human
Subjects
Argonne National Laboratory
ANL-95-93003 Huberman $0.00 0
Analysis of Differentiation Markers in Normal and Leukemic Blood Cells
ANL-97-96/001 Brown-VanHoozer $0.00 12
Validating a Model of the Effect of Operator Information Processing Behavior on Performance
Site Totals: 2 Projects $0.00 12
Brookhaven National Laboratory
BNL-77-146 Sutherland $1,000.00 2
DNA Repair - Human and E. Coli Photoreactivating Enzymes
BNL-86-203 Fowler $0.00 0
Localization of Functional Brain Monoamine Oxidase with 11-C-Clorgyline, 11-C-Deprenyl and PET
BNL-88-217 Fowler $0.00 0
The Use of Oxygen-15-Labeled Water to Assess Cerebral Blood Flow
BNL-89-222 Wielopolski $223,285.00 36
New and Old Models in Body Composition: Ethnic Specificity
BNL-89-225 Wielopolski $223,285.00 43
Nutritional and Intestinal Consequences of Immunodeficiency States
BNL-90-229 Srivastava $0.00 0
Sn-117m (4+) DTPA in the Treatment of Osseous Metastases
BNL-91-C15 Breitenstein $175,000.00 3,200
Health Surveillance System
BNL-91-C24 Sutherland $30,000.00 30
Photoreactivation in Human Skin
BNL-92-243 Fowler $5,000.00 1
Dopamine D2 Receptor Availability Measured with Carbon-11-Labeled Raclopride
BNL-93-249 Fowler $0.00 0
Imaging the Dopamine Presynaptic Neuron with 11-C Methylphenidate
BNL-94-144B Fowler $15,000.00 5
Evaluation of 18-FDG in the Diagnosis of Glucose Metabolism in the Human Body (Cocaine Abusers)
BNL-94-144C Fowler $15,000.00 5
Evaluation of 18-FDG in the Diagnosis of Glucose Metabolism in the Human Body (Tumors)
BNL-94-144D Fowler $36,000.00 12
Evaluation of 18-FDG in the Diagnosis of Glucose Metabolism in the Human Body (Alcoholics)
BNL-94-144E Fowler $89,000.00 33
Evaluation of 18-FDG in the Diagnosis of Glucose Metabolism in the Human Body (Alzheimer's)
BNL-94-144F Fowler $0.00 0
Evaluation of 18-FDG in the Diagnosis of Glucose Metabolism in the Human Body (Schizophrenics)
BNL-94-255 Fowler $0.00 0
11-C-L-Deprenyl-D2 for MAO B Mapping
BNL-94-257 Kaplan $0.00 0
Improvement of Fission Track Analysis (FTA) of Urine Samples from the Nuclear Test Personnel Program at USDSWA
BNL-94-258 Fowler $187,000.00 15
Studies of Brain Aging
BNL-94-C25 Dilmanian $0.00 0
Studies of Human Anatomical Specimens with the Multiple Energy Computed Tomography (MECT) System at the NSLS
BNL-95-255B Fowler $0.00 0
11-C-L-Deprenyl-D2 and 18-FDG for Study of Neurodegenerative Diseases
BNL-95-255C Fowler $0.00 0
[11C]Clorgyline for MAO A Mapping and [11C]L-Deprenyl-D2 for MAO B Mapping
BNL-95-260A Coderre $50,000.00 0
Boron Neutron Capture Therapy (BNCT) of Glioblastoma Multiforme at the BMRR (Prior Radiation)
BNL-96-249C Fowler $0.00 0
Dopamine Transporter Occupancy by Oral Methylphenidate
BNL-96-257B Kaplan $0.00 0
Blood and Urine Analysis for Pu-239
BNL-96-258B Fowler $65,000.00 5
Studies of Alcohol Withdrawal
BNL-96-265 Springer $499,000.00 52
General Magnetic Resonance Imaging (MRI) and Spectroscopic (MRS) Studies of Human Subjects
BNL-96-266 Coderre $500,000.00 6
BNCT of GBM at the BMRR: A Phase I/II Dose Escalation Study
BNL-96-268 Fowler $110,000.00 9
Brain Imaging Studies in Obesity
BNL-96-270 Wielopolski $223,285.00 82
Weight Loss: Bone and Muscle Skeletal Homeostasis
BNL-97-243E Fowler $45,000.00 9
Effects of Exercise on 11C-Raclopride Binding and Test-Retest Reproducibility for Measured 11C-Raclopride Binding Obtained with 2D and 3D Acquisition Modes
BNL-97-264 Susskind $5,000.00 1
99m Tc DTPA Lung Clearance in Radiation Injury
BNL-97-271 Morrison $150,000.00 1
Quantitative Studies on the Oncogenic and Cytogenetic Effects of Energetic Iron Particles in Mammalian Cells
BNL-97-274 Srivastava $0.00 0
Biodistribution of Tin-117m Stannic Citrate
BNL-97-276 Wielopolski $0.00 0
3-Methylhistidine Kinetics as an Indicator of Muscle Mass and Metabolism
BNL-98-266A Coderre $750,000.00 7
Boron Neutron Capture Therapy of Glioblastoma Multiforme at the Brookhaven Medical Research Reactor: A Phase I/II Dose Escalation Study (FDA IND 43,317, Protocol #5)
BNL-98-277 Fowler $109,000.00 9
Brain Imaging Studies in Methamphetamine Abusers
BNL-98-278 Hetherington $120,000.00 18
Spectroscopic Evaluation of Human Epilepsy
BNL-98-279 Fowler $90,000.00 9
PET Studies of the Effects of Tobacco Smoke on the Human Brain
BNL-98-280 Volkow $75,000.00 15
Spectroscopic Studies in Drug Abusers
BNL-98-281 Pan $30,000.00 5
Cerebral Metabolism in Ketosis and Epilepsy: A Spectroscopic Study at 4T
BNL-98-282 Pan $40,000.00 30
Evaluation of Multiple Sclerosis by 1H MR Spectroscopy
BNL-98-283 Pan $30,000.00 4
Cerebral Metabolism in Functional Stimulation: A Combined 1H-13C Magnetic Resonance and PET Study
BNL-98-284 Fowler $200,000.00 10
PET Evaluation of the Effect of Ginko Biloba on Brain Monoamine Oxidase (MAO)
BNL-98-285 Pan $60,000.00 9
Regional Ethanol Uptake Kinetics and MRI Visibility of Human Brain by 1H MRI Imaging
BNL-98-286 Coderre $100,000.00 2
Two Fraction Boron Neutron Capture Therapy of Debulked Glioblastoma Multiforme at the Brookhaven Medical Research Reactor: A Phase I/II Dose Escalation Study (FDA IND 43,317, Protocol #6)
BNL-98-287 Coderre $100,000.00 1
Two Fraction Boron Neutron Capture Therapy of Non-Debulked Glioblastoma Multiforme at the Brookhaven Medical Research Reactor: A Phase I/II Dose Escalation Study (FDA IND 43,317, Protocol #7)
BNL-98-288 Coderre $100,000.00 1
Boron Neutron Capture Therapy of Recurrent Glioblastoma Multiforme at the Brookhaven Medical Research Reactor: A Phase I/II Dose Escalation Study (FDA IND 43,317, Protocol #8)
BNL-98-289 Fowler $130,000.00 7
PET Studies of L-Deprenyl (Selegiline)
BNL-98-290 Capala $0.00 0
Lymphocyte Damage Following Irradiation at the BMRR
BNL-98-291 Fowler $0.00 0
Determination of DAT Occupancy by Oral Doses of Methylphenidate
BNL-98-292 Fowler $0.00 0
Determination of DAT Occupancy by Intravenous Methlyphenidate
BNL-98-293 Fowler $210,000.00 11
Determination of DAT Occupancy by Cocaine as a Function of Different Routes of Administration (Intravenous, Snorted and Smoked)
BNL-98-294 Fowler $85,000.00 5
Determination of DAT Occupancy by Cocaine after an Oral Dose of Methylphenidate
BNL-98-295 Fowler $0.00 0
PET Studies of Cocaine Abuse: Response to Methylphenidate
BNL-98-296 Rooney $75,000.00 27
Brain Water Content and Blood-Brain Barrier Permeability in Multiple Sclerosis
BNL-99-297 Fowler $90,000.00 6
PET Studies of Dopamine Receptor Availability: Effects of Exercise
BNL-99-298 Fowler $15,000.00 1
PET Studies of Radiotracers and Labeled Drugs in the Human Body: [11C]Clorgyline
BNL-99-300 Fowler $0.00 0
PET Studies of Dopamine Receptor Availability: Dose Response of Methylphenidate
BNL-99-301 Fowler $23,000.00 1
PET Studies of Alcoholism: Measurement of Brain Glucose Metabolism and Dopamine Activity in Alcoholics During Early and Late Detoxification
BNL-99-302 Fowler $0.00 0
PET Studies of Alcoholism: Measurement of Brain Metabolism and Brain Dopamine Concentration with 18FDG and 11C-Raclopride
BNL-99-303 Ding $0.00 0
PET Studies in Humans with C-11 Labeled Methadone
BNL-99-304 Fowler $42,000.00 6
PET Studies of Cocaine Abuse: Evaluation of Brain GABA Activity
BNL-99-305 Fowler $0.00 0
PET Studies of Phentermine
BNL-99-306 Fowler $145,000.00 9
PET Studies of the Relationship Between Dopamine Transporter Occupancy by Methylphenidate and Changes in Brain Dopamine
BNL-99-307 Lee $150,000.00 27
Evaluation of Cerebral Blood Vessel Function in Drug Abusers
BNL-99-308 Wang $21,000.00 7
Effect of Boron Neutron Capture Therapy on Glucose Metabolism of Glioblastoma Multiforme and Normal Brain
BNL-99-310 Fowler $96,000.00 14
Comparison of Brain Function as Measured in the MRI Environment to that Measured in the PET Environment
BNL-99-311 Wielopolski $90,000.00 10
The Use of Adjuvant Nutrition Prevents Muscle Wasting in AIDS Patients
BNL-99-312 Rooney $0.00 0
Magnetic Field Dependence of Water Proton Relaxation in Human Brain
BNL-99-313 Pan $0.00 0
MR Spectroscopic Imaging of Glutamate in Malignant Gliomas of Brain Tumor Patients with Epilepsy
BNL-99-314 Stein $0.00 0
Mechanisms of Fat Induced Insulin Resistance
BNL-99-317 Fowler $12,000.00 2
PET Studies of Alcoholism: Measurement of the Effect of Alcohol Intoxication on Brain Glucose Metabolism
BNL-99-318 Pan $10,000.00 1
MR Measurements of Cerebral Metabolism in Fasting and Visual Stimulation
BNL-99-319 Pan $0.00 0
MR Investigation of Brain Metabolism in Fasting and Ketosis Using Beta-Hydroxybutyrate Infusions
BNL-99-320 Fowler $0.00 0
PET Studies of the Brain Serotonin Systems with [11C]N-Methylspiroperidol
BNL-99-C31 Breitenstein $0.00 0
Brookhaven National Laboratory Employee Cancer Incidence Evaluation
BNL-99-C32 Hsiao $0.00 0
Hair Test for Breast Cancer
BNL-99-C33 Dunn $0.00 0
Vaccine Intervention for Lyme Borreliosis
Site Totals: 78 Projects $5,644,855.00 3,801
Fermilab Neutron Therapy Facility
FNAL-98-98-98-01 Shafer $10,000.00 15
Impedance-Controlled Microcurrent Therapy for Cancer Treatment Sequelae
Site Totals: 1 Project $10,000.00 15
Idaho National Engineering and Environmental Laboratory
INEEL-90-95-001 Hartenstein $9,000.00 15
Federal Aviation Administration (FAA) Explosive Detection System and Independent Validation and Verification Project
INEEL-95-004 Shell $50,000.00 100
Concealed Weapons Detection System
INEEL-97-INEEL-97-001 Thompson $37,500.00 20
Development of Immunological Sensor Test Kits for Forensic Samples
INEEL-98-INEEL-IRB-98-002 English $750.00 8
Performance Test for Detection of Explosives
INEEL-99-1 Hallbert $198,000.00 45
INEEL Human System Simulation Enterprise
INEEL-99-4 Nigg $0.00 32
Tissue-Boron Analysis
Site Totals: 6 Projects $295,250.00 220
Lawrence Berkeley National Laboratory
LBNL-75-001-H02 Budinger $3,000.00 2
Experimental Medicine Clinical
LBNL-75-102-H01 Castro $0.00 0
Treatment of Cancer with Heavy Charged Particles
LBNL-77-057-H02 Rubin $0.00 0
Studies of Lipoproteins and Lipid Protein Interactions
LBNL-79-106-H02 Krauss $50,000.00 361
Lipoproteins and Atherogenesis in Transgenic Animals
LBNL-79-108-H01 Stampfer $607,000.00 1
Characterization of Human Mammary Cells
LBNL-80-001-H01 Budinger $0.00 0
Myocardial Flow, Function, and Metabolism by PET & MRI
LBNL-82-001-H04 Budinger $0.00 0
Quantitative Cardiovascular Research
LBNL-84-001-H03 Budinger $15,000.00 10
Alzheimer's Disease as a Systemic Disorder
LBNL-88-107-H07 Williams $0.00 0
Lipoprotein Subfractions and Coronary Heart Disease During 25-Year Follow-Up
LBNL-90-007-H01 Melhorn $0.00 30
Hemoglobin Conversion to Pro-Oxidants by Cigarette Smoke
LBNL-90-068-H01 Narla $38,480.00 5
Red Cell Deformability In Vitro and Survival In Vivo
LBNL-90-107-H02 Williams $0.00 0
Weight Set Point and HDL Levels in Long-Distance Runners
LBNL-91-068-H03 Narla $145,800.00 17
Red Cell Membrane
LBNL-91-107-H01 Williams $550,000.00 23,000
National Runner's Health Study
LBNL-92-065-H01 Maguire $5,000.00 1
The Oxidant and Antioxidant Balance in Wounds (Leukocyte Function in Periodontal Disease)
LBNL-92-068-H02 Narla $28,900.00 8
Rheological and Adherence Properties of Sickle Cells
LBNL-92-106-H04 Krauss $300,000.00 102
Genetic and Metabolic Factors Affecting Response of Lp(a) to Dietary Fat
LBNL-92-107-H05 Williams $0.00 70
Effects of Running on HDL and LDL Subclasses of MZ Twins
LBNL-94-093-H01 Tribble $10,000.00 36
Modulation of Oxidant Stress-Mediated Atherosclerosis (Formerly: Oxidative Implications of Lipoprotein Heterogeneity)
LBNL-94-114-H02 Lockett $40,000.00 3
3-D Analysis of Genetic Instability in Breast Cancer
LBNL-95-073-H03 Jagust $0.00 0
Subcortical Infarction, Cortical Metabolism and Dementia
LBNL-95-109-H01 Fisk $0.00 0
Healthy Buildings Intervention Research
LBNL-96-068-H04 Narla $0.00 1
Cellular Consequences of Hemoglobin Membrane Structure
LBNL-97-001-H05 Budinger $0.00 0
122-I Generator and Radiotracers for Perfusion Studies
LBNL-97-057-H03 Forte $53,000.00 16
Plasma Antioxidative Enzymes as Indicators of Smoke Injury
LBNL-98-087-H01 Eberling $0.00 0
Brain Imaging with [F-18]-Fluorometatyrosine in Parkinson's Disease
LBNL-98-106-H06 Krauss $0.00 141
Genetic Testing for Evaluation of Heart Disease Risk
LBNL-98-107-H06 Williams $345,000.00 1,983
National Health Survey on the Internet
LBNL-98-110-H03 Nordahl $0.00 6
Sex Differences of Dopamine Metabolism
LBNL-98-139-H01 Moses $0.00 0
Breast Cancer Specific PET Instrumentation
LBNL-99-106-H07 Krauss $5,000.00 4
Evaluation of the Safety and Efficacy of Nicostatin (A combination tablet of Niacin extended-release/Lovastatin immediate-release)
LBNL-99-107-H07 Williams $0.00 0
Effects of Genes on the Relationship of Lifestyle to Disease
LBNL-99-109-H02 Fisk $0.00 0
Health and Productivity Intervention Study
LBNL-99-133-H02 Snow $0.00 16
Development of Improved Methods for the Detection of Sensitivity to Beryllium in Human Beings and the Identification of Immunologic and Genetic Factors Which Determine this Sensitivity
LBNL-99-146-H01 Hazen $168,500.00 25
Bioremediation Education, Science and Technology Program
LBNL-99-99-H01 Goth-Goldstein $0.00 0
Gene-Environment Interactions Related to Breast Cancer
Site Totals: 36 Projects $2,364,680.00 25,838
Lawrence Livermore National Laboratory
LLNL-88-105 Jones $1,400,360.00 202
Radiation Genotoxicity from Chernobyl Accident
LLNL-88-111 Tucker $10,000.00 3
Cytogenetic Studies
LLNL-89-106 Biermann $60,000.00 3
Protective Breathing Equipment (Respirators) Testing
LLNL-90-105 Carrano $1,600,000.00 3
LLNL Human Genome Center
LLNL-90-108 Wyrobek $120,000.00 3
Detection of Aneuploid Human Sperm by In-Situ Hybridization and Image Analysis
LLNL-91-102 Langlois $190,000.00 12
Glycophorin A-based Somatic Cell Mutation Measurements in Blood Samples from Normal Individuals
LLNL-92-105 Tittiranonda $170,000.00 50
The Effects of Ergonomically Designed Computer Keyboards on the Incidence of Cumulative Trauma Disorders among VDT Workers
LLNL-94-105 Wyrobek $120,000.00 12
Investigation of the Relationship between Numerical Chromosomal Aneuploidy in Sperm and Offspring
LLNL-95-115 Felton $50,000.00 8
Linking a Dietary Carcinogen to Cancer Suspectibility (formally called Determining Metabolism Differences by Urine Analysis)
LLNL-95-119 Lucas $30,000.00 2
Background Translocation Frequencies in Humans
LLNL-95-126 Turteltaub $150,000.00 5
Influence of Heterocyclic Amine Metabolic Polymorphisms on Bioactivation of PhIP in the Human Colon
LLNL-96-103 Turteltaub $50,000.00 6
Does Tamoxifen cause DNA Damage in Human Tissues
LLNL-96-106 Lucas $10,000.00 30
Chernobyl Dosimetry
LLNL-96-108 Tucker $10,000.00 232
Genetic and Molecular Analysis of a Normal Human Population
LLNL-96-109 Wyrobek $120,000.00 10
Age Effects on the Incidence of Genetic and Physiological Defects in Human Sperm
LLNL-96-111 Burnett $40,000.00 3
MIR Speech Science Experiments on the Human Vocal Tract
LLNL-96-113 Vogel $0.00 0
The Dynamics of Folate Metabloism in Adults
LLNL-96-114 Colston $50,000.00 3
Optical Diagnosis of Periodontal Disease
LLNL-97-102 Bench $100,000.00 14
Assessment of Dermal Exposure to Metals and Metal Compounds
LLNL-97-110 Stubbs $32,000.00 0
Generation of Contiguous Sequence-Ready DNA Clones in Human and Mouse
LLNL-98-102 Lucas $130,000.00 20
Evaluation of Chromosome Damage to Uranium Workers in Namibia for Assessment of Health Risk.
LLNL-98-104 Vogel $10,000.00 1
Elucidating Dynamics of Beta-Carotene Metabolism in Adults
LLNL-98-105 Everett $20,000.00 2
Optical Diagnosis through Blood
LLNL-98-106 Mendelsohn $75,000.00 7,757
Melanoma and other Mortality Rates in LLNL Employees
LLNL-98-111 Tucker $30,000.00 2
Chromosome Aberration Persistence Study
LLNL-98-112 Tucker $60,000.00 0
Perchloroethylene Exposure Study
LLNL-98-121 Sathyam $5,000.00 0
Optical Diagnosis of Skin Abnormalities
LLNL-98-122 Colston $25,000.00 1
Design of a Knee Immobilizer
LLNL-98-97-116 Layton $250,000.00 138
LLNL/AHS Study of Home-Cooked Foods
LLNL-99-104 Wyrobek $140,000.00 20
Molecular Genetic Analysis of Infertility in Men
LLNL-99-105 Colston $75,000.00 15
Dental Optical Coherence Tomography
LLNL-99-106 Lucas $0.00 0
Long-term Bioindicator for Radiation Exposure
LLNL-99-108 Christian $0.00 0
Analysis of Prostate Cancer Progression using Single Microdissected Cells and Comparative Genomic Hybridization
LLNL-99-109 Vogel $0.00 0
Absorbed Beta-Carotene: A Retinoid Source in Humans
LLNL-99-115 Kinney $30,000.00 79
Characterization of Dentin
LLNL-99-117 Jones $300,000.00 0
Methods Development for Studies of Genetic Damage and DNA Repair Function
LLNL-99-118 Johnson $3,500.00 73
Naturally Occuring Uranium in Urine
LLNL-99-119 Demos $0.00 0
Endoscopic Sub-Surface Optical Imaging for Cancer Detection
LLNL-99-121 Keating $0.00 0
Improved Measurement of Cholinesterase Inhibition
LLNL-99-125 Burgin $8,000.00 4
Silica Measurements to Test Effectiveness of Engineering Controls during Jackhammer Operations
Site Totals: 40 Projects $5,473,860.00 8,713
Los Alamos National Laboratory
LANL-52-91 LANL 06 Voelz $0.00 16
Manhattan Project Plutonium Workers Health Study
LANL-76-90 LANL 07 Reinert $200,000.00 6
Acceptance Testing for Air-Line Supplied Air-Suits
LANL-91-03 Sklar $0.00 0
Ligand-Receptor G Protein Dynamics and Neutrophil Response
LANL-96-05 Marrone $350,000.00 101
The Development of Improved Methods for the Detection of Individual Sensitivity to Beryllium (see LLNL-98-109 FY99 database)
LANL-98-01 Wray $425,000.00 2
Development and Testing of A Fieldable Prototype Noninvasive Intracranial Pressure Measurement System
LANL-98-02 Kraus, Jr. $980,000.00 5
Neuromagnetic Mapping of Functional Centers in the Human Brain
LANL-98-03 Lehnert $120,000.00 1
Use of Human Peripheral Blood Samples in Structure Function Based Poisoning of Anthrax Toxins
LANL-98-04 Lehnert $130,000.00 1
Use of Human Peripheral Blood Samples in Structural Biology of Bacterial Toxins
LANL-99-02 Noonan $500.00 27
Development of Improved Methods for the Detection of Individual Sensitivitiy to Beryllium and Identification of Immunologic and Genetic Factors
Site Totals: 9 Projects $2,205,500.00 159
Oak Ridge Institute for Science and Education
ORAU-78-96 Goans $50,000.00 4
Use of Ca-DTPA and Zn-DTPA for Chelation Therapy of Heavy Metals
ORAU-79-63 Goans $25,000.00 157
The U.S. Radiation Accident Registry Follow-Up Program
ORAU-80-58 Cragle $860.00 62
Whole Blood Procurement, Consent for Research Waiver Form and Payment Authorization
ORAU-80-60 Cragle $72,286.00 23,000
Comprehensive Epidemiology Study of Department of Energy Atomic Workers
ORAU-80-61 Goans $25,000.00 3
The DTPA Registry Follow-Up Program
ORAU-89-60a Cragle $0.00 0
Amendment - Comprehensive Epidemiology Study of Department of Energy Atomic Workers: National Death Index
ORAU-91-81 Goans $0.00 0
Use of Prussian Blue for Internal Decontamination of Radiocesium
ORAU-91-82a Cragle $404.00 29
Studies to Establish and Define ORAU Laboratory Standards for Lymphocyte Proliferation Tests (LPT)
ORAU-92-102 Aldrich $860,000.00 168
Medical Monitoring Program for Former Radiation Workers at Rocky Flats
ORAU-92-87 Cragle $0.00 0
Y-12 Beryllium Workers Follow-up Study, Phase II: Screening for Beryllium Sensitivity and Definitive Diagnosis of Chronic Beryllium Disease
ORAU-99-101 Ellis $30,000.00 21,271
Follow Up of Former Brookhaven National Laboratory Workers
ORAU-99-103 Ellis $62,000.00 451
Survey on Parental Trade-off of Risk from Diarrheal Illness Against Vaccine Adverse Event, Plus Willingness to Pay to Avoid Illness and Adverse Event.
ORAU-99-60b Cragle $22,090.00 10,000
Amendment - Comprehensive Epidemiology Study of Department of Energy Atomic Workers: Worker Notification
ORAU-99-87a Cragle $2,704,134.00 1,838
Beryllium Workers Follow-up Study, Phase II: Screening for Beryllium Sensitivity and Definitive Diagnosis of Chronic Beryllium Disease. Amendment - to add Former Beryllium Workers at all DOE sites where Beryllium was used.
Site Totals: 14 Projects $3,851,774.00 56,983
Oak Ridge National Laboratory
ORNL-93-17 Jenkins $185,000.00 2,007
Measurement of Environmental Tobacco Smoke Constituents in Occupied Spaces
ORNL-94-33 Buchanan $90,000.00 30
Characterization of Components of Fingerprints
ORNL-94-38 Draper $50,000.00 4
Advanced Robotics for Remanufacturing and Aircraft Support Functions
ORNL-98-17a Jenkins $85,000.00 24
Measurement of Environmental Tobacco Smoke Constituents in Occupied Spaces. Phase III
ORNL-98-47 Gailey $14,100.00 16
Biomarkers of Magnetic Field Exposure
ORNL-98-56 Sega $0.00 50
Study of Neurotransmitters in Children with ADD or ADHD
ORNL-99-57 Tufano $100,000.00 0
Driver Research by the Human Systems Research Group
ORNL-99-58 Spelt $44,000.00 0
In-Vehicle Information Integration Study
Site Totals: 8 Projects $568,100.00 2,131
Pacific Northwest National Laboratory
PNNL-93-3-1 Fix $108,000.00 0
Comprehensive Epidemiologic Data Resource (CEDR) Related Tasks
PNNL-96-1 Collins $50,000.00 1
Imaging Neurological Processes of the Human Brain
PNNL-96-20 Cameron $180,000.00 50
Study of Heat Stress and Performance in Carpenters at DOE Sites
PNNL-96-4 Richman $10,000.00 15
Field Evaluation of Polarized and Full Spectrum Polarized Lighting
PNNL-97-1 Barnhart $205,000.00 150
Comprehensive Occupational Health Surveillance
PNNL-97-6 Roye $15,000.00 45
Inherited Breast Cancer, Identification, Education, Counseling and Testing of High Risk Patients in a Military Setting
PNNL-97-8 Thrall $15,000.00 20
Fundamental Research on Solvent-laden Soils
PNNL-98-5 Mong $30,000.00 50
Advanced Techniques in Latent Fingerprint and Visualization
PNNL-99-2 Thrall $15,000.00 9
Field Study at Hanford's 222S Facility
PNNL-99-5 Stapp $0.00 0
Hanford Cultural Resources Project
Site Totals: 10 Projects $628,000.00 340
Rocky Flats Environmental Technology Site
RFET-91-RF-94-06 Newman $587,623.00 522
Rocky Flats Beryllium Health Surveillance Program: Current Workers
Site Totals: 1 Project $587,623.00 522
Sandia National Laboratories
SNL-98-01 Sandoval $0.00 0
Border Warning/Intrusion Detection Radar
SNL-98-02 Swahlan $2,400.00 1
Power and Thermal Tool Testing
SNL-98-03 Zelicoff $85,000.00 2,000
Hepatitis C Research Study
SNL-98-07 Boswell $0.00 0
Development and Evaluation of a Stress-Based Health Promotion Model in an Organizational Setting Using Structured Equation Modeling
SNL-99-06 Wenner $3,500.00 1
Visual Inspection Reliability Program
SNL-99-08 Buckle $35,000.00 58
Facilal Verification System Evaluation
Site Totals: 6 Projects $125,900.00 2,060
Sub-Totals: 211 Projects $21,755,542.00 100,794


Non-DOE Facilities:
Project IdentifierPrincipal Investigator Funding# Human
Subjects
Agency for Toxic Substances and Disease Registry
ATSDR-96-1594 Tatham $0.00 0
Hanford Infant Mortality and Fetal Death Analysis
ATSDR-96-1624 Burg $0.00 7,000
National Exposure Registry: Iodine-131 Subregistry Site Specific Protocol, Hanford Nuclear Reservation, State of Washington
Site Totals: 2 Projects $0.00 7,000
Beckman Laser Institute/UC Irvine
BLI-91-ER61227 Berns $1,600.00 1
A Center of Excellence for Laser Applications in Medicine
Site Totals: 1 Project $1,600.00 1
Beth Israel Deaconess Medical Center
BIDMC-94-1 Busse $100,000.00 0
Phase-I BNCT Trial of Peripheral Melanoma
BIDMC-96-2 Busse $1,540,000.00 5
Phase-I BNCT Trial of Glioblastoma Multiforme and Metastatic Melanoma to the Brain
Site Totals: 2 Projects $1,640,000.00 5
City University of New York
CUNY-98-H-9735 Spielman $8,000.00 11
Near Infrared Spectroscopy (NIRS) in Patients with Obstructive Sleep Apnea Syndromes
CUNY-98-H9938-C Alfano $0.00 0
Breast Cancer Program: Optical Mammography
CUNY-99-H9939-C Alfano $0.00 0
Subsurface Imaging for Detection of Skin Lesions, such as Melanoma, Using Polarization Imaging
CUNY-99-MTC/YALE Alfano $1,000.00 5
Hormone Levels Probed by Fluorescence Spectroscopy of the Female Genitalia
Site Totals: 4 Projects $9,000.00 16
Columbia University
CU-93-62433 Bergmann $131,371.00 9
Detection and Assessment Using Position Emission Tomography of Defects in Myocardial Fatty Acid Utilization Leading to Cardiomyopathy
Site Totals: 1 Project $131,371.00 9
Columbia University - Eye Research
CU-95-95EH89658 Worgul $400,000.00 11,368
Ocular Radiation Effects in Chernobyl Liquidators
Site Totals: 1 Project $400,000.00 11,368
Consortium for Risk Evaluation w/ Stakeholder Participation
CRESP-95-E96-108 Burger $50,000.00 650
Use of Ecological Resources at DOE Sites
CRESP-95-X-0887 Wartenberg $70,000.00 16,489
An Update of The Worker Cohort Mortality Study at Nuclear Fuels Production Facility on the Savannah River site
CRESP-96-27-0009-E Takaro $0.00 0
Laboratory Evaluation of Field Collected Cells
CRESP-96-E97-026 Greenberg $6,500.00 97
CRESP Social, Landuse, Demographic, Geographic, and Economic (SLUDGE) Surveys and Interviews
CRESP-97-26-0807-B/C Faustman $42,321.00 11
Human Reproductive Effects of Controlled Toluene Exposure
CRESP-97-27-0228-C Takaro $110,000.00 125
Screening for Chronic Beryllium Disease at Hanford
CRESP-97-27-0295-X Faustman $12,500.00 0
Analysis of Gene Expression changes in Isolated Uroepitheleal cells
Site Totals: 7 Projects $291,321.00 17,372
Lovelace Respiratory Research Institute
LRRI-95-IRB#96027 Guilmette $450,000.00 58
In Vivo Measurements of Lead-210 in Former Uranium Miners (IRB#96027; formerly listed as LRRI-95-IRB#95-030/IRB#96027 in FY98 database)
Site Totals: 1 Project $450,000.00 58
National Academy of Sciences (NAS)
NAS-90-DEFG0590ER60960 Douple $11,800,000.00 2,677
Activities of National Academy of Sciences in Relation to the Radiation Effects Research Foundation (RERF)
Site Totals: 1 Project $11,800,000.00 2,677
National Institute for Occupational Safety and Health
NIOSH-92-002 Schubauer-Berig $469,000.00 105,000
Cohort Mortality Study of Idaho National Engineering and Environmental Laboratory (INEEL)
NIOSH-93-003 Rinsky $238,600.00 38,000
Cohort Mortality Study of Portsmouth Naval Shipyard (PNS), Kittery, Maine
NIOSH-93-013 Morin $309,000.00 23,000
Cancer Incidence Study of Rocky Flats Plant
NIOSH-94-018 Wilkinson $60,000.00 69,313
Mortality Among Female Nuclear Weapons Workers
NIOSH-94-019 Bigbee $3,200.00 12
Glycophorin A Biodosimetry in I-131 Treated Patients
NIOSH-95-004 Wenzl $525,000.00 95,000
Leukemia Case-Control Study
NIOSH-95-005 Jiggens $289,800.00 47,941
Study of Multiple Myeloma among Workers at the Oak Ridge Gaseous Diffusion Plant (K-25)
NIOSH-95-014 Cardis $39,000.00 600,000
International Collaborative Study of Nuclear Industry Workers
NIOSH-95-015 Pepper $492,000.00 5,894
Prevention of Stress and Health Consequences of Downsizing and Reorganization
NIOSH-95-016 Rosenman $322,000.00 5,111
Chronic Beryllium Disease Among Beryllium-Exposed Workers
NIOSH-95-017 Newman $322,000.00 109
Beryllium Disease Natural History and Exposure Response
NIOSH-95-020 Stram $190,656.00 3,347
Measurement Error Methods for Underground Miner Studies
NIOSH-95-021 Newman $0.00 18,000
Lung Fibrosis in Plutonium Workers
NIOSH-95-022 Rosenman $0.00 2
Study of Heat Stress and Performance in Carpenters at DOE Sites
NIOSH-95-033 Barnhart $3,200.00 491
Comprehensive Occupational Health Surveillance
NIOSH-95-034 Bingham $3,200.00 1
Work Histories - Evaluating New Participatory Methods
NIOSH-95-035 Ruttenber $3,200.00 1
Sentinel Exposure Event Surveillance/Evaluation at DOE Sites
NIOSH-95-036 Froines $3,200.00 1
Hazard Surveillance in the Defense Nuclear Industry
NIOSH-96-008 Grajewski $450,000.00 4,668
Cohort Mortality Study of Pantex Plant, Amarillo, Texas
NIOSH-96-010 Wald $0.00 59
Acute Radiation Syndrome in Russian Nuclear Workers
NIOSH-96-023 Wing $0.00 60,000
Ionizing Radiation and Mortality Among Hanford Workers
NIOSH-97-001 Rinsky $2,000.00 9,000
Case-Control Study of the Portsmouth Gaseous Diffusion Plant
NIOSH-97-007 Robinson $388,000.00 5,000
Cohort Mortality Study of DOE Chemical Laboratory Workers
NIOSH-97-026 Lambert $119,851.00 500
Epidemiologic Studies to Evaluate Health Effects of Uranium Milling
NIOSH-98-009 Silver $388,000.00 28,000
Lung Cancer Case-Control Study
NIOSH-98-032 Brodkin $62,613.00 102
Surveillance Methods for Solvent-Related Hepatotoxicity
NIOSH-99-006 Xue $102,231.00 1
Correcting for Measurement Errors in Radiation Exposure
NIOSH-99-011 Newman $265,729.00 1
Dose of Beryllium Causing Sensitization and Disease
NIOSH-99-012 Pinney $223,413.00 7,300
Radon and Cigarette Smoking Exposure Assessment in Fernald Workers
NIOSH-99-024 Cardis $189,352.00 1
Reconstruction of Doses for Chernobyl Liquidators
NIOSH-99-025 Ruttenber $177,805.00 1
Uncertainty Analysis for Characterizing Plutonium Exp/Lung Cancer
Site Totals: 31 Projects $5,642,050.00 1,125,856
Sloan-Kettering Institute for Cancer Research
SKI-86-ER60407 Larson $1,000.00 1
Improving Cancer Treatment with Cyclotron Produced Radionuclides
SKI-95-ER62039 Larson $0.00 0
Pharmacokinetics of Genetically Engineered Antibody Forms Using Positron Emission Tomography
Site Totals: 2 Projects $1,000.00 1
St. Mary's Hospital Saccomanno Research Institute
SMHSRI-95-DE-FG03-95ER62060/A0 Carstea $257,449.00 100
Identification of Human Lung Cancer Susceptibility Genes
SMHSRI-97-DE-FG02-90E60939 Saccomanno $79,293.00 250
Early Lung Cancer Detection in Uranium Miners with Abnormal Sputum Cytology
Site Totals: 2 Projects $336,742.00 350
The Ohio State University
OSU-95-95H0240 Goodman $58,400.00 0
Pharmacokinetics and Biodistribution of Sodium Borocaptate in Patients with Anaplastic Astrocytomas / Glioblastoma Multiforme
Site Totals: 1 Project $58,400.00 0
UCLA School of Medicine, Department of Pathology
UCLA-87-ER-60548 Gatti $290,000.00 0
Human Gene for Radiation Hypersensitivity
Site Totals: 1 Project $290,000.00 0
University of California, Los Angeles
UCLA-92-640 Small $0.00 0
Dopamine Transport and Storage Measured with DOPA
UCLA-93-654 Schelbert $0.00 0
Assessment of Myocardial Viability by N-13 Ammonia, F-18 Deoxyglucose and Positron Emission Tomography
UCLA-95-117 Schelbert $12,000.00 52
Measurement of Myocardial Blood Flow with N-13 Ammonia
UCLA-95-450 Czernin $0.00 0
Significance of Cardiac Allograft Vasculopathy
UCLA-96-082 Gambhir $0.00 0
Sparing/Recovery of Function after Hemispherectomy: Analysis with Functional Imaging
UCLA-96-426 Schelbert $0.00 0
Response of Coronary Vasomotion to Intravenous L-Arginine
UCLA-98-021 Eisenberg $0.00 0
Human Subject Research Under Structural Biology & Molecular Medicine Research Program
UCLA-98-039 Small $5,000.00 5
Beta-Amyloid Probes of Alzheimer's Disease
UCLA-98-062 Czernin $10,000.00 5
FDG PET for Evaluating Patients with a Pelvic Mass
UCLA-99-061 Schelbert $0.00 0
Repeat Measurements of Myocardial Blood Flow with N-13 Ammonia and PET During Cold Pressor Testing
Site Totals: 10 Projects $27,000.00 62
University of Michigan Hospitals
UMH-87-DE-FG02-87ER60561 Kuhl $49,200.00 23
Advancing PET Science for New Measures of Brain Function
Site Totals: 1 Project $49,200.00 23
University of Tennessee Medical Center-Knoxville
UTMC-93-IRB-0555 Kabalka $65,000.00 3
An Evaluation of Fluorine-18 Labeled BPA-F in Patients with Glioblastoma Multiforme Using Positron Emission Tomography (PET)
Site Totals: 1 Project $65,000.00 3
University of Vermont
UVT-97-DE-FG07-96ER62331 Albertini $108,152.00 5
A Novel Biomarker for Beryllium Sensitization in Humans
Site Totals: 1 Project $108,152.00 5
University of Washington
UWA-92-UWA-95-1085-E07 Trask $495,000.00 14
Analytical Cytogenetics and Gene Mapping (previously identified by UWA-96-26-009-E; new number will stay with the project for its lifetime)
Site Totals: 1 Project $495,000.00 14
Washington State University
WASU-68-50181 Filipy $1,235,000.00 900
United States Transuranium and Uranium Registries
Site Totals: 1 Project $1,235,000.00 900
Sub-Totals: 72 Projects $23,504,636.00 1,165,720


Former Workers Project projects:
Project IdentifierPrincipal Investigator Funding# Human
Subjects
Boston University School of Public Health
BUSPH-96-DE-FC03-96SF21261 Pepper $790,000.00 600
Medical Surveillance for Former Department of Energy Workers at the Nevada Test Site
Site Totals: 1 Project $790,000.00 600
Colorado University Health Sciences Center
CUHSC-96-DE-FC03-96SF21259 Ruttenber $20,000.00 75
Medical Monitoring Program for Former Rocky Flats Workers
Site Totals: 1 Project $20,000.00 75
Johns Hopkins University School of Hygiene and Public Health
JHUSHP-97-DE-FC03-98SF21541 Schwartz $580,000.00 162
Medical Surveillance for Former Department of Energy Workers
Site Totals: 1 Project $580,000.00 162
Medical University of South Carolina
MUSC-97-DE-FC03-97SF21513 Hoel $784,098.00 500
Savannah River Site Former Production Workers Health Surveillance Program
Site Totals: 1 Project $784,098.00 500
Paper, Allied-Industrial, Chemical and Energy Workers International Union
PACE-96-DE-FC03-96SF21260 Wages $1,000,000.00 363
DOE Gaseous Diffusion Plants K-25, Portsmouth, and Paducah Former Workers Medical Surveillance Program
PACE-97-DE-FC03-97SF21512 Markowitz $0.00 0
Medical Surveillance For Former INEEL Workers
Site Totals: 2 Projects $1,000,000.00 363
The Center to Protect Workers' Rights
CPWR-96-DE-FC03-96SF21262 Ringen $790,000.00 1,000
Hanford Building Trades Medical Screening Project
CPWR-97-DE-FC03-97SF21514 Ringen $790,000.00 1,500
The Augusta Building Trades Medical Screening Program for the Savannah River Site
Site Totals: 2 Projects $1,580,000.00 2,500
University of Cincinnati
UOC-96-DE-FC03-96SF21263 Bingham $790,000.00 502
Medical Surveillance Program for Construction Workers at Oak Ridge, TN : Phase II
Site Totals: 1 Project $790,000.00 502
University of Washington
UOW-96-DE-FC03-96SF21258 Barnhart $789,000.00 5,692
Medical Surveillance Program/Former DOE Hanford Production Workers
Site Totals: 1 Project $789,000.00 5,692
Sub-Totals: 10 Projects $6,333,098.00 10,394


National Center for Environmental Health projects:
Project IdentifierPrincipal Investigator Funding# Human
Subjects
Fred Hutchinson Cancer Research Center
FHCRC-89-CDC-200-89-0716 Davis $1,300,000.00 3,500
Hanford Thyroid Disease Study
Site Totals: 1 Project $1,300,000.00 3,500
University of Colorado Health Sciences Center
UCHSC-92-U50/CCU808715 Ruttenber $250,000.00 650
Epidemiologic Evaluation of Childhood Leukemia and Paternal Exposure to Ionizing Radiation
Site Totals: 1 Project $250,000.00 650
Sub-Totals: 2 Projects $1,550,000.00 4,150

Grand Totals: 295 Projects $52,669,476.00 1,281,058