USDOE Human Subjects Research Database, fiscal year 1995

Lawrence Berkeley National Laboratory

Project Identifier: LBNL-92-068-H02

Project Title:

Rheological and Adherence Properties of Sickle Cells (see LBL-94-1-66 in 1994 database)

Principle Investigator: Dr. Mohandas Narla

Project started in: 1992

Fiscal Year 1995 Funding for Research on Human Subjects:

Project Funding Information:
Project received funding in Fiscal Year 1995.
Project used human subjects in Fiscal Year 1995.

Funding Sources:

Non-DOE Federal: National Institutes of Health (NIH)

Amount: $250,354 (Est.)
Comments:

Grant number HL-31579

Information on Use of Human Subjects:

Project does not involve use of multiple protocols/subprojects.

IRB Review:
Type of Review: Full Board
Most Recent Approval: February 17, 1995
IRB Approval Number: 95-2-108

Number of Human Subjects in the Last Reporting Period for this Project: 10
(Reporting periods vary.)

Type of Human Subjects Involvement:

Collection of Bodily Materials:

Collection of personally identifiable bodily materials (blood or blood products, cells, tissue, organs, waste).

• Use of bodily materials collected from subjects specifically for this project.

(a. Objectives, b. Methodology, c. Ionizing Radiation, Radioactive Substances, or Chemical Substances to which human subjects are exposed, d. Involvement of Human Subjects [d.1. procedures used, d.2. risks if any])

OBJECTIVES

The objective of this study is to continue the characterization of rheological and adherence properties of sickle cells and define the biochemical and structural basis for the observed alterations in these properties. In so doing, the study will aid the development of better diagnostic and treatment tools for patients with the sickle cell condition.

METHODOLOGY

Blood samples for analysis are obtained by venipuncture. Some samples are obtained from blood donors with sickle cell or other thalassemias.

IONIZING RADIATION, RADIOACTIVE SUBSTANCES, OR CHEMICAL SUBSTANCES

None.

INVOLVEMENT OF AND RISKS TO HUMAN SUBJECTS

Human subject involvement is limited to the donation of blood for analysis via routine clinical venipuncture, which carries with it small risks of bruising or bleeding and a remote risk of infection.