USDOE Human Subjects Research Database, fiscal year 1995

Lawrence Berkeley National Laboratory

Project Identifier: LBNL-90-007-H01

Project Title:

Hemoglobin Conversion to Pro-Oxidants by Cigarette Smoke (see LBL-93-6-63 in 1994 database)

Principle Investigator: Dr. Rolf J. Melhorn

Project started in: 1990

Fiscal Year 1995 Funding for Research on Human Subjects:

Project Funding Information:
Project received funding in Fiscal Year 1995.
Project used human subjects in Fiscal Year 1995.

Funding Sources:

Non-Federal: Tobacco Related Disease Program

Amount: $107,500 (Est.)

Information on Use of Human Subjects:

Project does not involve use of multiple protocols/subprojects.

IRB Review:
Type of Review: Full Board
Most Recent Approval: February 17, 1995
IRB Approval Number: 95-2-107

Number of Human Subjects in the Last Reporting Period for this Project: 0
(Reporting periods vary.)

Type of Human Subjects Involvement:

Collection of Bodily Materials:

Collection of personally identifiable bodily materials (blood or blood products, cells, tissue, organs, waste).

• Use of existing bodily materials that were collected for another purpose or project.

(a. Objectives, b. Methodology, c. Ionizing Radiation, Radioactive Substances, or Chemical Substances to which human subjects are exposed, d. Involvement of Human Subjects [d.1. procedures used, d.2. risks if any])

OBJECTIVES

The objective of this study is to use isolated erythrocytes and/or hemoglobin exposed in vitro to cigarette smoke to test the hypothesis that the exposure of blood to cigarette smoke promotes the formation of free radicals by hemoglobin products. This information will help enable more informed decisions about the risks and likely results of cigarette smoking.

METHODOLOGY

Blood collected under another protocol (see below) is used as the source for the isolated erythrocytes and hemoglobin which are analyzed.

IONIZING RADIATION, RADIOACTIVE SUBSTANCES, OR CHEMICAL SUBSTANCES

None.

INVOLVEMENT OF AND RISKS TO HUMAN SUBJECTS

Human involvement in this study is limited to the analysis of blood collected under another protocol, "Metabolic & Genetic Origins of Lipoprotein Subclasses" (subprotocol 6), LBNL-79-106-H02 (R. Krauss, principal investigator).