Brookhaven National Laboratory

Project Identifier: BNL-94-C21

Project Title:

Studies of DNA Repair in Twins

Principle Investigator: Dr. Michael A. Bender

Project started in: 1994

Project Funding Information:
Project did not receive funding in Fiscal Year 1995.
Project did not use human subjects in Fiscal Year 1995.

Explanation:

Funding not received.

Project does not involve use of multiple protocols/subprojects.

IRB Review:
Type of Review: Full Board
Most Recent Approval: October 04, 1995

Number of Human Subjects in the Last Reporting Period for this Project: 0
(Reporting periods vary.)

Type of Human Subjects Involvement:

Collection of Bodily Materials:

Collection of personally identifiable bodily materials (blood or blood products, cells, tissue, organs, waste).

Abstract:

(a. Objectives, b. Methodology, c. Ionizing Radiation, Radioactive Substances, or Chemical Substances to which human subjects are exposed, d. Involvement of Human Subjects [d.1. procedures used, d.2. risks if any]): The objective of the proposed study is to determine the contribution of genetic variation in DNA repair and P450 liver enzyme activity to variation among people in response to DNA damaging agents. At BNL, we will study the spontaneous and induced (a monofunctional and a bifunctional alkylating agent) frequency of sister chromatid exhanges in peripheral blood lymphocytes from a group of 300 monozygous and dizygous twins. 75 subjects will be studied during the first year, 150 in each of the next three years, and 75 during the last year. Blood will be drawn at Virginia Commonwealth University (VCU) in Richmond, Virginia under approval of the University's Institutional Review Board. Complementary studies of P450 liver enzyme status will be done on the same blood samples at VCU and also at the University of Toronto in Canada. The risk to the subjects may be a slight possibility of infection and localized bleeding into the tissues from the blood withdrawal. No subjects will participate at BNL.