USDOE Human Subjects Research Database, fiscal year 1995

Brookhaven National Laboratory

Project Identifier: BNL-94-257

Project Title:

Improvement of Fission Track Analysis (FTA) of Urine Samples from the Nuclear Test Personnel Program at USDNA

Principle Investigator: Dr. Edward Kaplan

Project started in: 1994

Fiscal Year 1995 Funding for Research on Human Subjects:

Project Funding Information:
Project received funding in Fiscal Year 1995.
Project used human subjects in Fiscal Year 1995.

Funding Sources:

Non-DOE Federal: Defense Nuclear Agency (USDNA)

Amount: $5,000 (Est.)

Information on Use of Human Subjects:

Project does not involve use of multiple protocols/subprojects.

IRB Review:
Type of Review: Full Board
Most Recent Approval: May 03, 1995

Number of Human Subjects in the Last Reporting Period for this Project: 22
(Reporting periods vary.)

Type of Human Subjects Involvement:

Collection of Bodily Materials:

Collection of personally identifiable bodily materials (blood or blood products, cells, tissue, organs, waste).

• Use of bodily materials collected from subjects specifically for this project.

(a. Objectives, b. Methodology, c. Ionizing Radiation, Radioactive Substances, or Chemical Substances to which human subjects are exposed, d. Involvement of Human Subjects [d.1. procedures used, d.2. risks if any])

Twenty-four hour urine collections from approximately 30 individuals will be examined using a fission track procedure to quantitate excretion of plutonium-239. In time periods months and years after exposure, the urinary excretion can be related to body burden. Also measured is urinary creatinine as an indication of completeness of collection. This is a pilot study which will be extended to volunteers in other geographic areas of the country and eventually to Armed Forces veterans who participated in tests of nuclear weapons.

There are no risks to human subjects in this project.