USDOE Human Subjects Research Database, fiscal year 1995

Brookhaven National Laboratory

Project Identifier: BNL-93-C17

Project Title:

Purification of Human Plasminogen

Principle Investigator: Dr. Walter Mangel

Project started in: 1993

Fiscal Year 1995 Funding for Research on Human Subjects:

Project Funding Information:
Project did not receive funding in Fiscal Year 1995.
Project did not use human subjects in Fiscal Year 1995.

Explanation:

Funding was not received for this project. No subjects were studied.

Information on Use of Human Subjects:

Project does not involve use of multiple protocols/subprojects.

IRB Review:
Type of Review: Full Board
Most Recent Approval: February 01, 1995

Number of Human Subjects in the Last Reporting Period for this Project: 0
(Reporting periods vary.)

Type of Human Subjects Involvement:

Collection of Bodily Materials:

Collection of personally identifiable bodily materials (blood or blood products, cells, tissue, organs, waste).

• Use of existing bodily materials that were collected for another purpose or project.

(a. Objectives, b. Methodology, c. Ionizing Radiation, Radioactive Substances, or Chemical Substances to which human subjects are exposed, d. Involvement of Human Subjects [d.1. procedures used, d.2. risks if any])

The purpose of this experiment is to characterize the kinetics of the conformational change that occurs in plasminogen upon the binding of the ligand epsilon-amino caproic acid. This conformational change is physiologically important in that it determines whether plasminogen can be activated. The activation of plasminogen is involved in destruction of the blood clots that lead to heart attack and stroke. It is also subverted by tumor cells in that it enables them to metastasize. Seventy units of blood will be obtained from the Long Island blood bank. There is no risk to human subjects from this protocol.