USDOE Human Subjects Research Database, fiscal year 1995

Brookhaven National Laboratory

Project Identifier: BNL-91-C24

Project Title:

Photoreactivation in Human Skin

Principle Investigator: Dr. Betsy Sutherland

Project started in: 1991

Fiscal Year 1995 Funding for Research on Human Subjects:

Project Funding Information:
Project received funding in Fiscal Year 1995.
Project used human subjects in Fiscal Year 1995.

Funding Sources:

DOE: Office of Health and Environmental Research (OHER)

Amount: $5,000 (Est.)

Information on Use of Human Subjects:

Project does not involve use of multiple protocols/subprojects.

IRB Review:
Type of Review: Full Board
Most Recent Approval: March 01, 1995

Number of Human Subjects in the Last Reporting Period for this Project: 2
(Reporting periods vary.)

Type of Human Subjects Involvement:

Collection of Bodily Materials:

Collection of personally identifiable bodily materials (blood or blood products, cells, tissue, organs, waste).

• Use of existing bodily materials that were collected for another purpose or project.

(a. Objectives, b. Methodology, c. Ionizing Radiation, Radioactive Substances, or Chemical Substances to which human subjects are exposed, d. Involvement of Human Subjects [d.1. procedures used, d.2. risks if any])

We are investigating DNA repair enzymes and their role in repair in humans. In collaboration with Harvard Medical School and Massachusetts General Hospital, healthy human volunteers are exposed to ultraviolet or visible light, and biopsies obtained immediately after or after time for repair. The biopsies are returned to BNL for analysis. We carry out approximately 20 studies per year, with a maximum of four subjects studied at one time; about 5 of these are repeat studies. We also study human neonatal foreskins (10-15/year) obtained from Suffolk Central or Brookhaven Hospital. The tissue, which would otherwise be discarded, serves as an excellent source of human tissue for studies of DNA damage and for initiation of cell cultures for in vitro studies. Anonymity of mother and child is maintained to preserve confidentiality; because of the nature of the tissue, no subject is sampled more than once.