USDOE Human Subjects Research Database, Fiscal Year 2006

University of Alabama at Birmingham

Public Information Contact:

Dr. Robert P. Kimberly
Department of Medicine
Division of Clinical Immunology and Rheumatology
SHEL 172, 1825 University Blvd.
Birmingham, AL 35294

Phone: 205-934-5306
Fax: 205-934-1564
E-mail: rpk@uab.edu

Institutional Review Board (IRB):

Projects are approved by an IRB located at: University of Alabama at Birmingham
The approving IRB operates under an OHRP assurance.
OHRP assurance number: FWA00005960

Human Subject Projects:

Number of Human Subjects projects reported: 1

UAB-04-X040607001 ""Program in the Functional Genomics of Autoimmunity and Immunobiology""

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Project Identifier: UAB-04-X040607001

Project Title:

""Program in the Functional Genomics of Autoimmunity and Immunobiology""

Principal Investigator: Dr. Robert P. Kimberly, University of Alabama at Birmingham

Project started in: 2004
This project ended in fiscal year 2006.

Project Funding Information:

This project did not receive funding during fiscal year 2006.
Explanation: This project's DOE funding was limited to the period 9/1/2004-8/31/2005. No future funding is anticipated. Analyses were completed during that period. By filing this report, we "close" the project.

Information on Use of Human Subjects:

This project does not involve the use of multiple protocols/subprojects.
Identifier or number: X040607001
Institutional Review Board (IRB) Review:
Type of Review: Expedited
Approving Institution: University of Alabama at Birmingham
Most recent approval: 07/20/05
IRB approval number: X040607001
Explanation of IRB approval:
The renewal of the IRB status of this project is currently pending. However, no patients have been enrolled in this study since the project period of 9/1/2004-8/31/2005.
Number of human subjects who participated in this project/protocol/subproject in the last reporting period: 0
Reporting period for number of human subjects: Other: 09/01/04 to 08/31/05
Explanation:
Pateint recruitment and study analyses for the DOE-funded project were limited to the funding period listed above. No further enrollment has occurred, and future analyses are not anticipated presently.

Type(s) of Human Subjects Involvement:

Collection of personally identifiable bodily materials (blood or blood products, urine, cells, tissue, teeth, organs, excreta, etc):

Using cells cultured in a laboratory.
Using existing specimens or samples of bodily materials collected for another purpose.

Abstract:

(a. Objectives, b. Methodology, c. Ionizing Radiation, Radioactive Substances, or Chemical Substances to which human subjects are exposed, d. Involvement of Human Subjects [d.1. procedures used, d.2. risks if any])

Polymeric immunoglobulin receptor (pIgR) is a transmembrane glycoprotein on the basolateral surface of secretory epithelial cells. It mediates the transport of dimeric IgA and polymeric IgM across mucosal epithelia. Regulation of IgA transport through pIgR may play an important role in the levels of IgA and its relation to pathogenesis. pIgR is located on human chromosome 1q32, a region of genetic linkage for systemic lupus erythematosis (SLE), and is a strong candidate gene for SLE susceptibility. We used direct sequencing techniques to identify single nucleotide polymorphisms (SNPs) in the pIgR gene in Caucasian and African American controls and SLE patients and to test for association with SLE phenotype. The study cohort comprises of 50 controls and 50 SLE patients from the African American and Caucasian ethnic groups. Four significant SNPs in the pIgR gene were identified by DNA direct sequencing in 191 ethnically diverse donors. Some of SNP alleles were enriched in SLE patient groups, indicating these SNPs may play important roles in autoimmune and other inflammatory diseases.

Go to list of projects at University of Alabama at Birmingham